ITTC Project


Identifying Epostatic Interactions in Autism Spectrum Disorders

Project Award Date: 08-01-2010



Description

To date, several candidate genes have been examined to evaluate their possible associations with autism. These genes have been selected based on supportive linkage evidence or the presence of certain findings at the clinical level in people with an autism spectrum disorder (ASD). Given that individuals with ASD are clinically heterogeneous, it is not surprising that most of the observed DNA sequence changes in possible Autism genes have not been reproduced in other studies. It is very likely that epigenetic factors (not identified by traditional genetic screening methods) play a role in the etiology of these disorders.

ITTC researchers will develop novel bioinformatics methods for the identification of genes and gene pathways implicated in autism through a comprehensive analysis of microRNA, mRNA, and splicing expression profiling. This is the first comprehensive research study (beyond the genomic sequence) to evaluate posttranscriptional modifications of mRNAs influenced by noncoding RNAs in association with autism. The study of gene expression and splicing pattern in autism by evaluating microRNAs will provide a link between autism and epigenetic factors.


Investigators

Faculty Investigator(s): Xue-wen Chen (PI)

Student Investigator(s): Bing Han


Project Sponsors


Primary Sponsor(s): Kansas City Area Life Sciences Institute


Partner with ITTC

The Information and Telecommunication Technology Center at the University of Kansas has developed several assistance policies that enhance interactions between the Center and local, Kansas, or national companies. 

ITTC assistance includes initial free consulting (normally one to five hours). If additional support is needed, ITTC will offer one of the following approaches: 

Sponsored Research Agreement

Individuals and organizations can enter into agreements with KUCR/ITTC and provide funds for sponsored research to be performed at ITTC with the assistance of faculty, staff and students.

Licensing and Royalty/Equity Agreement

An ITTC goal is the development of investment-grade technologies for transfer to, and marketing by, local, Kansas, and national businesses. To enhance this process, the Center has developed flexible policies that allow for licensing, royalty, and equity arrangements to meet both the needs of ITTC and the company.

Commercialization Development

Companies with a technology need that can be satisfied with ITTC's resources can look to us for assistance. We can develop a relationship with interested partners that will provide for the development of a technology suited for commercialization.

ITTC Resource Access

ITTC resources, including computers and software systems, may be made available to Kansas companies in accordance with the Center's mission and applicable Regents and University policies.

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