ITTC Project

Computational Prediction of Beta-Sheet Arrangement (K-INBRE)

Project Award Date: 07-01-2005


It is widely believed that protein misfolding into beta aggregates or fibrils is a significant contributor to the onset of Alzheimers, Parkinsons, and other neurodegenerative diseases. Although knowledge of the mechanism for conformational change may be critical to control of these diseases, considerable uncertainty exists about the nature of aggregate formation and the nature of the fibrils. Computational prediction of the transformation may present a plausible approach to resolving some of the uncertainties. Use of long-range interactions in prediction of ?-strand arrangement in the formation of ?-sheets may well be an essential step to forecasting/determining the 3-D structure of proteins from amino acid sequences. Thus, a better understanding of ?-strand arrangement in ?-sheets will not only provide possible solutions to prevent intermolecular ?-sheet formation associated with neurodegenerative diseases but may also contribute to the success of 3-D structure prediction.


Faculty Investigator(s): Jianwen Fang (PI)

Project Sponsors

Primary Sponsor(s): University of Kansas Medical Center Research Institute, Inc. (KUMCRI)

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